Once again, it’s Nobel Prize time. The first prize to be awarded, as expected, was for Physiology and Medicine and went to Craig Mello and Andrew Fire. Mello and Fire were awarded for their discovery of
a fundamental mechanism for controlling the flow of genetic information
namely what is now known as RNA interference or RNAi. Uncommonly for a Nobel Prize, this year’s award came relatively soon after the discovery to which is referred. The paper describing Fire’s and Mello’s work was published in 1998 on Nature. This has been interpreted as a sign of the outstanding importance of their discovery since usually it takes decades for a work to be recognized valuable of such an award. Now, the very fact that someone is publishing a work that is so important to inaugurate a brand new field from scratch is definitely rare and it is something that every scientist dream about. It does happen periodically and many times is, indeed, well recognized for instance with a Nobel Prize. What is very rare, though, it’s the discovery to come out of the blue, completely unexpected. Was this the case for Fire’s Work (he was the corresponding author in the paper)?